An extensive plasmid library for preparing tau variants and studying their functional biochemistry

development and implementation of an optimized control strategy for induction machine in an electric vehicle

in the area of automotive engineering there is a tendency to more electrification of power train. in this work control of an induction machine for the application of electric vehicle is investigated. through the changing operating point of the machine, adapting the rotor magnetization current seems to be useful to increase the machines efficiency. in the literature there are many approaches wh...

Neuronal Models for Studying Tau Pathology

Alzheimer's disease (AD) is the most frequent neurodegenerative disorder leading to dementia in the aged human population. It is characterized by the presence of two main pathological hallmarks in the brain: senile plaques containing beta-amyloid peptide and neurofibrillary tangles (NFTs), consisting of fibrillar polymers of abnormally phosphorylated tau protein. Both of these histological char...

“studying Digital Library Users

A technical system may be viewed as a locus of knowledge production. Knowledge grows through the design process, as the designer constructs new solutions to problems. Donald Schon (1983, 1990) describes a conversation between the designer and the materials of design, an interaction in which the designer makes a move – either with the actual artifact or with a sketch or other representation of i...

The influence of two functional genetic variants of GRK5 on tau phosphorylation and their association with Alzheimer's disease risk

Our work explores the relationship between G protein-coupled receptor kinase-5 (GRK5) single nucleotide polymorphisms and Alzheimer's disease risk. We confirmed that GRK5 translocates from the cellular membrane to the cytosol in the hippocampus of Alzheimer's disease mice and that GRK5 deficiency promotes tau hyperphosphorylation, a hallmark of Alzheimer's disease pathology. Our results indicat...

Preparing for Publication: Strategies for Identifying Potential Library Journals